**Independiente Santa Fe host Once Caldas in a Copa Colombia clash that's basically a David vs. Goliath matchup — except Santa Fe's the one missing half their squad.** The visitors arrive with decent form and a defensive edge, but Santa Fe's got the head-to-head bragging rights and a streaky run that's kept them competitive. 🔴

Santa Fe are battle-tested at home despite a mountain of injuries, while Once Caldas come off a tidy 2-0 road win over Medellín. The visitors have won just twice in five but look sharper in transition; Santa Fe lean on experience and their massive H2H advantage.

Key storylines:

- **H. Rodallega** and **F. Fagúndez** carry Santa Fe's attacking load with key defenders sidelined — depth will be tested.
- Once Caldas' backline of **A. Correa**, **D. Londoño**, and **J. Cardona** must weather Santa Fe's home intensity and their **J. Obrian**–**J. Torres** midfield drive.
- The **Copa format** and injury crisis create uncertainty; Once Caldas' solidity could exploit Santa Fe's rotating pieces.

Expected lineups:

- **Independiente Santa Fe**: W. Asprilla, C. Mafla, E. Olivera, I. Scarpeta, H. Palacios, J. Obrian, J. Torres, D. Torres, K. Toscano, F. Fagúndez, H. Rodallega
- **Once Caldas**: F. Parra, A. Correa, D. Londoño, J. Cardona, J. D. Cuesta, Andres Colorado, J. Quiñónes, M. Barrios, A. Roa, J. Zapata, D. Moreno

Prediction:

**Santa Fe 1–1 Once Caldas.** Home advantage and H2H form give Santa Fe a slight edge, but injuries and Once Caldas' defensive discipline make this a coin flip. 🎲